1,1'-Carbonyldiimidazole → HCID 13211795, compound

Participants

Reaction Steps

In this reference example, a solution of 631 mg of 1-benzyl-4-(2-amino-cylohexylamino)-piperidine in a free form obtained in Reference Example 17 and 550 mg of 1,1'-carbonyldiimidazole in 10 ml of acetonitrile is stirred at room temperature for 12 hours. The deposited crystals are separated by filtration, washed with acetonitrile and then dried to obtain 383 mg of crude crystals. The crude crystals are recrystallized from 34 ml of isopropanol to obtain 300 mg of the desired product.

Provenance & Evidence