HCID 20244815, compound → HCID 20244742, compound

HRID 647849Notes

Reaction equation

HRID 647849 reaction equation
[NH2:1][CH:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-])=O)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[H][H]>C(O)C.[Pd]>[NH2:1][CH:2]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:16])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

5

Reactant 2

HCID 20244815HCID 20244815, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20244742HCID 20244742, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl 2-amino-4-(2-nitrophenyl)butyrate (27 g) in ethanol (600 ml) was hydrogenated at room temperature and atmospheric pressure, using 10% palladium on charcoal (2.5 g) as catalyst, until hydrogen uptake ceased. The catalyst was filtered off and evaporation to dryness gave ethyl 2-amino-4-(2-aminophenyl)butyrate used without purification for the next synthetic step.

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationThe catalyst was filtered off
  3. customevaporation to dryness

Sources & evidence

ORD record
ord-ed807c1bd737430fbecc525b0ce87ac6
Source dataset
uspto-grants-1983_10
Patent number
US04410520

Reaction notes

Loading…