HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dl-Phenylalanine → D-phenylalanine N-carbobenzoxy-D-aspartic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dl-Phenylalanine | HCID 994 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | (2R)-2-(((benzyloxy)carbonyl)amino)butanedioic acid | HCID 5289152 | — |
| Solvent | Water | HCID 962 | — |
| Product | D-phenylalanine N-carbobenzoxy-D-aspartic acid | HCID 13714281 | 32.1% |
Reaction Steps
Eight grams of DL-phenylalanine and 1.2 g of sulfuric acid was suspended in 100 ml of water at 40° C. Ten grams of N-carbobenzoxy-D-aspartic acid was added to the solution over five hours, while this solution was continuously stirred. The resulting crystal was separated, washed with 10 ml of water and dried to give 5.2 g of a D-phenylalanine N-carbobenzoxy-D-aspartic acid. Analysis revealed that the optical purity of the D-phenylalnine was 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04610827 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-987bea95ecff469face1ae081f9f5f8e |
| Source note | uspto-grants-1986_09 |