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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 647885Generated: October 30, 2026

Ethyl 2-amino-4-phenylbutanoate → 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one

https://huagongshe.com/reaction/647885

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 2-amino-4-phenylbutanoateHCID 4646380—
ReactantEthyl 2-(2,3-dioxo-4,5-dihydro-1-benzazepin-1-yl)acetateHCID 13500724—
Product1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-oneHCID 13243517—

Reaction Steps

Ethyl 2-amino-4-phenylbutyrate is treated under conditions of reductive alkylation as described in the previous examples with 1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepine-2,3-dione to give 1-ethoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepine-2-one of example 10.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04410520
Source datasetuspto-grants-1983_10
ORD IDord-77b3c8d9079f469a8b7e128e37d4e250
Source noteuspto-grants-1983_10