Sodium Iodide → HCID 20484345, compound

Participants

Reaction Steps

2-Hydroxy-6-methoxybenzaldehyde (3.04 g, 0.02 M), 5-bromopentanonitrile (3.81 g, 0.02 M), anhydrous potassium carbonate (2.97 g), sodium iodide (0.12 g) and ethanol (15 ml) were refluxed with stirring for 41/2 hr. The cooled reaction mixture was filtered and the solid washed well with ethanol. The filtrate was evaporated to dryness and the residue partitioned between ether and water. The organic layer was separated and washed with 2 N sodium hydroxide solution water, dried (sodium sulphate) and evaporated to give 5-(2-formyl-3-methoxyphenoxy)pentanonitrile, 2.92 g, 63%, m.p. 71°-72° C. from benzene/petrol.

Provenance & Evidence