反应详情

149 g of 2,3-dichloropyrazine, 300 g of morpholine and 400 ml of water are stirred for 16 hours at 40° C. The reaction mixture is then extracted by shaking with ether. The ether extracts are washed with water until neutral, dried over sodium sulphate and evaporated in a waterpump vacuum. The residue is distilled in a waterpump vacuum. 2-Chloro-3-morpholinyl-pyrazine, boiling point 162°-165° C./15 mm Hg, is thus obtained.

1. extractionThe reaction mixture is then extracted
2. washThe ether extracts are washed with water until neutral,
3. dry with materialdried over sodium sulphate
4. customevaporated in a waterpump vacuum
5. distillationThe residue is distilled in a waterpump vacuum