Morpholine → 4-(3-Chloro-6-methylpyrazin-2-yl)morpholine

HRID 647967Notes

Reaction equation

HRID 647967 reaction equation
[Cl:1][C:2]1[C:7](Cl)=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>CCOCC>[Cl:1][C:2]1[C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[N:6][C:5]([CH3:9])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 128581342,3-Dichloro-5-methylpyrazine

Product 1

HCID 570620344-(3-Chloro-6-methylpyrazin-2-yl)morpholine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

16.3 g of 2,3-dichloro-5-methyl-pyrazine and 100 ml of morpholine are warmed to 100° C. for 6 hours. The reaction mixture is then diluted with 200 ml of ether and again extracted by shaking with water. The ether phase is dried over sodium sulphate and evaporated in a waterpump vacuum. The residue is distilled in a waterpump vacuum. 2-Chloro-3-morpholinyl-5-methyl-pyrazine, boiling point 166°-167° C./15 mm Hg, is thus obtained.

Workup

  1. extractionagain extracted
  2. dry with materialThe ether phase is dried over sodium sulphate
  3. customevaporated in a waterpump vacuum
  4. distillationThe residue is distilled in a waterpump vacuum

Sources & evidence

ORD record
ord-442bfea1f1c64e4ab0fe836cb66c86cd
Source dataset
uspto-grants-1983_10
Patent number
US04410530

Reaction notes

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