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Thionyl Chloride → 2,3-Dichloro-5-(chloromethyl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (5,6-Dichloropyridin-3-yl)methanol | HCID 21882961 | — |
| 生成物 | 2,3-Dichloro-5-(chloromethyl)pyridine | HCID 10176536 | — |
反応手順
2,3-Dichloro-5-hydroxymethyl-pyridine is reacted in a known manner with thionyl chloride to give 5-chloromethyl-2,3-dichloro-pyridine and the latter is reacted with sodium cyanide, without additional purification (for example analogously to L. A. Carlson et al., Acta Pharm. Suecica 9, 411 (1972)). 5,6-Dichloro-pyridine-3-acetonitrile, thus obtained, melts at 72°-75° C. after recrystallisation from ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04410530 |
| 出典データセット | uspto-grants-1983_10 |
| ORD ID | ord-906e38de8aae4bf6b7dc561e614fb8f0 |
| 出典メモ | uspto-grants-1983_10 |