HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanethiol → 1-[[3-(Ethylthio)-2-pyrazinyl]oxy]-3-[(1-methylethyl)amino]-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanethiol | HCID 6343 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 1-[(3-Chloropyrazin-2-yl)oxy]-3-[(propan-2-yl)amino]propan-2-ol | HCID 20483418 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[[3-(Ethylthio)-2-pyrazinyl]oxy]-3-[(1-methylethyl)amino]-2-propanol | HCID 20483454 | — |
Reaction Steps
Analogously to the description in Example 8, 7.5 g (0.03 mol) of 3-chloro-2-(3'-isopropylamino-2'-hydroxy-propoxy)-pyrazine, 2.8 g (0.045 mol) of ethyl-mercaptan and 2.4 g (0.045 mol) of sodium methylate in 150 ml of methanol, when refluxed for 30 hours, give the crude base 3-ethylthio-2-(3'-isopropylamino-2'-hydroxypropoxy)-pyrazine, and this is converted, with 1.74 g of fumaric acid, into the fumarate of melting point 158°-160° C. when crystallised from methanol-ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04410530 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-79b81bcca2e64becb29ea9d9e13f0260 |
| Source note | uspto-grants-1983_10 |