Benzoyl chloride → HCID 13487028, compound

Participants

Reaction Steps

A solution of the resulting ester (1.2 g., 0.006 moles) in dry xylene (50 ml.) containing benzoyl chloride (1.5 g., 0.01 moles) is heated at reflux temperature, in a nitrogen atmosphere, for 44 hours. The solvent is removed in vacuo and the residue is purified by t.l.c. on silica gel (hexane-ethyl acetate, 3:1) to give a product in 50% yield which, when crystallized from acetone hexane, gives methyl-3-benzoyl-5,6,7,8-tetrahydro-9H-pyrrolo[1,2,a]azepine-9-carboxylate having a m.p. 98°-99° C.

Provenance & Evidence