4-Fluorobenzoyl chloride → HCID 13487022, compound

Participants

Reaction Steps

A solution of methyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate (2.0 g., 0.01 moles) in dry xylene (30 ml.) containing 4-fluorobenzoyl chloride (4.5 g., 0.028 moles) is heated at reflux temperature in a nitrogen atmosphere for 20 hours. The solvent is removed in vacuo and the residue is purified by t.l.c. on silica gel using hexane-ethyl acetate (3:1) as the developing solvent. Removal of the solvent gives methyl-3-p-fluorobenzoyl-5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylate which, when crystallized from acetone-hexane exhibits a m.p. of 78°-79° C.

Provenance & Evidence