Carbon Dioxide → HCID 20260927, compound

HRID 648034Notes

Reaction equation

HRID 648034 reaction equation
Br[C:2]1[C:3]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][OH:14])=[CH:8][C:4]=2[S:5][C:6]=1[CH3:7].C([Li])CCC.[C:20](=[O:22])=[O:21].C1(C)C=CC=CC=1>CCOCC>[OH:14][CH2:13][CH2:12][C:9]1[CH:10]=[CH:11][C:3]2[C:2]([C:20]([OH:22])=[O:21])=[C:6]([CH3:7])[S:5][C:4]=2[CH:8]=1

Participants

6

Reactant 4

HCID 280Carbon DioxideHCID 1140TolueneHCID 20260917HCID 20260917, compoundHCID 178418339Butyllithium

Product 1

HCID 20260927HCID 20260927, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Successive treatment of 3-bromo-6-(2-hydroxyethyl)-2-methylbenzo[b]thiophene with n-butyl lithium in ether followed by carbon dioxide according to the method of Example 11(ii) gave 6-(2-hydroxyethyl)-2-methylbenzo[b]thiophene-3-carboxylic acid, m.p. 166°-169° C. (from toluene).

Sources & evidence

ORD record
ord-d7c881c0f3844d02aec4323ad131aa46
Source dataset
uspto-grants-1983_10
Patent number
US04410539

Reaction notes

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