Ammonia → HCID 70478702, compound

HRID 648043Notes

Reaction equation

HRID 648043 reaction equation
C[O:2][C:3]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]3[NH:16][CH:17]=[CH:18][N:19]=3)=[CH:10][C:8]=2[CH:9]=1)=O.[NH3:20]>C(O)C>[NH:19]1[CH:18]=[CH:17][N:16]=[C:15]1[CH2:14][C:11]1[CH:12]=[CH:13][C:7]2[O:6][C:5]([C:3]([NH2:20])=[O:2])=[CH:9][C:8]=2[CH:10]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 70478675HCID 70478675, compound

Product 1

HCID 70478702HCID 70478702, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-(1-imidazolylmethyl)benzofuran-2-carboxylic acid methyl ester in a concentrated solution of ammonia in ethanol (25 ml.) was stirred for 18 hours and then evaporated. The residue was crystallized from isopropanol to give 5-(1-imidazolylmethyl)benzofuran-2-carboxamide (0.60 g.), m.p. 174°-176° C.

Workup

  1. customevaporated
  2. customThe residue was crystallized from isopropanol

Sources & evidence

ORD record
ord-ccec0ce2698c4e9bbed3701112c96689
Source dataset
uspto-grants-1983_10
Patent number
US04410539

Reaction notes

Loading…