HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[2-(1-Imidazolyl)ethoxy]benzo[b]-thiophene-2-carboxylic acid hydrochloride hemihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-[2-(1-Imidazolyl)ethoxy]benzo[b]thiophene-2-carboxylic acid methyl ester | HCID 13663016 | — |
| Product | 5-[2-(1-Imidazolyl)ethoxy]benzo[b]-thiophene-2-carboxylic acid hydrochloride hemihydrate | HCID 70479054 | — |
Reaction Steps
A mixture of 5-[2-(1-imidazolyl)ethoxy]benzo[b]thiophene-2-carboxylic acid methyl ester (0.35 g.) and concentrated hydrochloric acid (5 ml.) was heated on a steam bath for 5 hours and then evaporated. The residue was crystallized twice from ethanol/ether to give 5-[2-(1-imidazolyl)ethoxy]benzo[b]-thiophene-2-carboxylic acid hydrochloride hemihydrate (0.23 g.), m.p. 255°-258° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04410539 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-1af2a8a5fe8e42319a652dda3c9bd9dc |
| Source note | uspto-grants-1983_10 |