Hydrazine hydrate (1:1) → HCID 20484846, compound

Participants

Reaction Conditions

Reaction Steps

500 mg of the product of Step B were added to 3 ml of acetic acid and 121 mg of hydrazine hydrate and the temperature rose spontaneously to 40° C. The acetic acid was distilled by heating the mixture up to 180° C. during which the majority of the acetic acid was removed. The mixture was cooled and water was added thereto. The mixture was extracted with chloroform and the organic phase was dried over magnesium sulfate and evaporated to dryness to obtain 520 mg of ethyl 4,5-dihydro-5,5-dimethyl-3-(2-hydroxy-2-methylpropyl)-[1H]-pyrazole-4-carboxylate in the form of a liquid.

Provenance & Evidence