HCID 20484846, compound → HCID 20484852, compound

HRID 648083Notes

Reaction equation

HRID 648083 reaction equation
[CH3:1][C:2]1([CH3:17])[NH:6][N:5]=[C:4]([CH2:7][C:8]([OH:11])([CH3:10])[CH3:9])[CH:3]1[C:12]([O:14][CH2:15][CH3:16])=[O:13]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:17][C:2]1([CH3:1])[C:3]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:4]([CH2:7][C:8]([OH:11])([CH3:10])[CH3:9])[N:5]=[N:6]1

Participants

4

Reactant 1

HCID 20484846HCID 20484846, compound

Product 1

HCID 20484852HCID 20484852, compoundYield 93.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

A suspension of 1.5 g of manganese dioxide in 50 ml of methylene chloride was stirred under an inert gas for 15 minutes and 200 mg of the product of Step C were added. The mixture was stirred for one hour and was filtered. The filtrate was evaporated to dryness to obtain 185 mg of ethyl 3,3-dimethyl-5-(2-hydroxy-2-methyl-propyl)-[3H]-pyrazole-4-carboxylate.

Workup

  1. stirringThe mixture was stirred for one hour
  2. filtrationwas filtered
  3. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-2439274f21904dc6a68356af8f4050f8
Source dataset
uspto-grants-1983_10
Patent number
US04410721

Reaction notes

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