反应详情

A solution of spiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (4.2 g), 3,5-dimethylpyrazole carboxamidine nitrate (3.6 g) in 95% ethanol (80 ml) is heated under reflux for 7 hours. The mixture is evaporated to dryness in vacuo and the viscous residue is triturated with ether. After filtration, the precipitate is twice recrystallized from ethyl acetate/methanol to yield product (2.6 g, 42%) as a solid, mp 188°.

1. temperatureunder reflux for 7 hours
2. customThe mixture is evaporated to dryness in vacuo
3. customthe viscous residue is triturated with ether
4. filtrationAfter filtration
5. customthe precipitate is twice recrystallized from ethyl acetate/methanol