Ethanol → HCID 12902572, compound

Participants

Reaction Steps

In 3 ml of a 12% ethanol solution of hydrogen chloride was dissolved 0.14 g of 10,11-dihydro-11-oxo-5H-dibenzo[a,d]cycloheptene-3-acetic acid obtained in Example 3. The solution was heated under reflux for 30 minutes with stirring. After the reaction, the reaction mixture was cooled, and the solvent was distilled off. Water was added to the residue, and the mixture was extracted with ether. The ethereal layer was washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate. Then, the ether was distilled off. The residue was chromatographed on a silica gel column using benzene as an eluent. From the eluate, 0.12 g of ethyl 10,11-dihydro-11-oxo-5H-dibenzo[a,d]cycloheptene-3-acetate was obtained as a slightly yellow oily substance.

Provenance & Evidence