Hydrochloric Acid → HCID 12740030, compound

Participants

Reaction Steps

In 2 ml of methanol was dissolved 0.1 g of methyl 10,11-dihydro-11-oxo-5H-dibenzo[a,d]cycloheptene-2-acetate obtained in Example 16, and 6 ml of a 10% aqueous solution of sodium hydroxide was added. The mixture was heated under reflux for 2 hours with stirring. After the reaction, the reaction mixture was cooled, and water was added. The mixture was acidified with 10% hydrochloric acid, and the precipitated solid was extracted with ether. The ethereal layer was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The ether was distilled off. Recrystallization of the residue from a mixture of ether and n-hexane afforded 0.082 g of 10,11-dihydro-11-oxo-5H-dibenzo[a,d]cycloheptene-2-acetic acid as colorless needle-like crystals having a melting point of 171° to 173° C.

Provenance & Evidence