Hydrogen Bromide → HCID 12740030, compound

Participants

Reaction Steps

Six milliliters of 47% hydrobromic acid was added to 0.32 g of methyl 11-methoxy-5H-dibenzo[a,d]cycloheptene-2-acetate obtained in Example 11, and the mixture was stirred at 100° to 125° C. for 30 minutes. After the reaction, the reaction mixture was cooled, and water was added. The mixture was extracted with ether. The ethereal layer was washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate. The ether was distilled off. Recrystallization of the residue from a mixture of methanol and n-hexane afforded 0.22 g of 10,11-dihydro-11-oxo-5H-dibenzo[a,d]cycloheptene-2-acetic acid as colorless needle-like crystals.

Provenance & Evidence