Water → HCID 13326264, compound

HRID 648170Notes

Reaction equation

HRID 648170 reaction equation
C(CC([N:6]([C:11]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:18])[NH:7][C:8]([NH2:10])=[O:9])=O)#N.[OH2:19].[OH-].[Na+]>C(O)C>[NH2:6][C:11]1[N:7]([NH:6][C:11]2[C:12]([CH3:18])=[CH:13][CH:14]=[CH:15][C:16]=2[CH3:17])[C:8](=[O:9])[NH:10][C:13](=[O:19])[CH:12]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 20459805HCID 20459805, compound

Product 1

HCID 13326264HCID 13326264, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

One mole of the above phenylsemicarbazide is added to 400 ml of water, followed by the addition of 200 ml of ethanol. This mixture is heated to 85° and 165 ml of 10% sodium hydroxide is added. After 30 minutes the mixture is acidified to pH 5, cooled to RT, filtered and recrystallized in acetone/water, yielding 6-amino-1-(2,6-dimethylanilino)-2,4-pyrimidinedione.

Workup

  1. temperatureThis mixture is heated to 85°
  2. filtrationfiltered
  3. customrecrystallized in acetone/water

Sources & evidence

ORD record
ord-985b75f863f946e29377292bf49eb385
Source dataset
uspto-grants-1983_10
Patent number
US04411839

Reaction notes

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