HCID 178516326, compound → HCID 178516327, compound

Participants

Reaction Steps

In 150 ml of methanol was dissolved 782 mg of Nα -[(S)-2-azetidinone-4-carbonyl]-L-histidyl-L-proline benzyl ester (12) and the compound (12) was hydrogenated for 2 hours at room temperature using 156 mg of 10% palladium-carbon as a catalyst. When the catalyst was filtered off and the filtrate was concentrated, 620 mg of Nα -[(S)-2-azetidinone-4-carbonyl]-L-histidyl-L-proline (13) was obtained.

Provenance & Evidence