HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178479208, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- | HCID 75657 | — |
| Reactant | Thiocarbohydrazide | HCID 2724189 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178479208 | HCID 178479208 | 56.4% |
Reaction Steps
To 200 ml of methanol is added 3.6 g (0.1 mole) of gaseous HCl followed by 12.7 g (0.1 mole) of O-methylcaprolactam and then 10.6 g (0.1 mole) of thiocarbohydrazide. After heating at reflux for 2 hours, the mixture is allowed to cool to room temperature and is refrigerated. The solid product is recrystallized twice from methanol/ethyl acetate, affording 13.4 g of 4-amino-5-(5-aminopentyl)-4H-1,2,4-triazole-3-thiol hydrochloride. m.p. 192°-194° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04411905 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-ac19bc616ca046238fd9335ecc49473e |
| Source note | uspto-grants-1983_10 |