HRID648197

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11208851

8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione

C13H20BrNO2

HCID13232475

3-(Piperazin-1-yl)-1,2-benzoxazole

C11H13N3O

PRODUCTS

生成物

结构：O.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2noc3ccccc23)CC1.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2noc3ccccc23)CC1

HCID70508187

未命名化合物

收率 40%

PROCEDURE

实验过程

Reaction of 8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione and 3-(1-piperazinyl)-1,2-benzisoxazole according to the procedure of Example 3 and crystallization of the free base from isopropanol affords a 40% yield of 8-[4-[4-(1,2-benzisoxazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hemihydrate, m.p. 96°-98° C.

WORKUP

后处理

customto the procedure of Example 3 and crystallization of the free base from isopropanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f8588dc3b2c5479da545fea02db9f01a
来源数据集: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04411901
来源说明: uspto-grants-1983_10

反应 SMILES

Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:15](=[O:16])[CH2:14][C:9]2([CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:8][C:7]1=[O:17].[N:18]1([C:24]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[O:26][N:25]=2)[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[OH2:16].[O:26]1[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:24]([N:18]2[CH2:19][CH2:20][N:21]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:15](=[O:16])[CH2:14][C:9]4([CH2:13][CH2:12][CH2:11][CH2:10]4)[CH2:8][C:7]3=[O:17])[CH2:22][CH2:23]2)=[N:25]1.[O:26]1[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:24]([N:18]2[CH2:19][CH2:20][N:21]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:15](=[O:16])[CH2:14][C:9]4([CH2:13][CH2:12][CH2:11][CH2:10]4)[CH2:8][C:7]3=[O:17])[CH2:22][CH2:23]2)=[N:25]1