3-(4-Bromobutyl)-1,3-thiazolidine-2,4-dione → 3-[4-[4-(1,2-Benzisoxazol-3-yl)-1-piperazinyl]butyl]-2,4-thiazolidinedione hydrate

HRID 648198Notes

Reaction equation

HRID 648198 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10](=[O:11])[CH2:9][S:8][C:7]1=[O:12].[N:13]1([C:19]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[O:21][N:20]=2)[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[OH2:11].[O:21]1[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:19]([N:13]2[CH2:14][CH2:15][N:16]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:10](=[O:11])[CH2:9][S:8][C:7]3=[O:12])[CH2:17][CH2:18]2)=[N:20]1

Participants

3

Reactant 2

HCID 130598253-(4-Bromobutyl)-1,3-thiazolidine-2,4-dioneHCID 132324753-(Piperazin-1-yl)-1,2-benzoxazole

Product 1

HCID 204569523-[4-[4-(1,2-Benzisoxazol-3-yl)-1-piperazinyl]butyl]-2,4-thiazolidinedione hydrateYield 44%

Procedure

Reaction of 3-(4-bromobutyl)-2,4-thiazolidinedione with 3-(1-piperazinyl)-1,2-benzisoxazole according to the procedure of Example 3 affords a 44% yield of 3-[4-[4-(1,2-benzisoxazol-3-yl)-1-piperazinyl]butyl]-2,4-thiazolidinedione hydrate, m.p. 104.5°-106.6° C., from methanol.

Sources & evidence

ORD record
ord-8d77c1e365d14c44ad0199cd19fa99da
Source dataset
uspto-grants-1983_10
Patent number
US04411901

Reaction notes

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