3-(Piperazin-1-yl)-1,2-benzoxazole → 4-[4-(1,2-Benzisoxazol-3-yl)-1-piperazinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride

Participants

Reaction Steps

Reaction of 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxane with 3-(1-piperazinyl)-1,2-benzisoxazole according to the procedure of Example 12 and conversion of the free base to the hydrochloride salt affords a 25% yield of 4-[4-(1,2-benzisoxazol-3-yl)-1-piperazinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride, m.p. 260°-262°, from methanol (25% yield).

Provenance & Evidence