Potassium Carbonate → N-[4-[[4-(Diphenylmethyl)-1-piperazinyl]methyl]-2-thiazolyl]acetamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-acetamido-4-chloromethylthiazole (7.6 g), 1-benzhydrylpiperazine (10.0 g) and potassium carbonate (5.5 g) in N,N-dimethylformamide (80 ml) was stirred at 80° C. for 2 hours. After the reaction mixture was poured into ice-water, the precipitated crystals were collected by filtration, washed with water and then crystallized twice from methanol to give white crystals (8.4 g) of 2-acetamido-4-(4-benzhydrylpiperazin-1-ylmethyl)thiazole, mp 178°-179° C.

Provenance & Evidence