Potassium Carbonate → HCID 20482399, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-acetamido-5-chloro-4-chloromethylthiazole (450 mg), 1-benzhydrylpiperazine (504 mg) and potassium carbonate (276 mg) in N,N-dimethylformamide (3 ml) was stirred at 70° C. for 20 minutes. After the reaction mixture was poured into ice-water, the precipitated crystals were collected by filtration, washed with water and then dried, followed by recrystallization from a mixture of ethyl acetate and n-hexane to obtain crystals (355 mg) of 2-acetamido-5-chloro-4-(4-benzhydrylpiperazin-1-ylmethyl)thiazole, mp 227°-230° C.

Provenance & Evidence