Water → HCID 20482448, compound

Participants

Reaction Steps

S-(2-Aminothiazol-4-ylmethyl)isothiourea dihydrochloride (2.6 g) and 4-benzhydryl-1-(2-chloroethyl)piperazine (3.87 g) were suspended in ethanol (50 ml) in a stream of nitrogen, and thereto was added at a time water (30 ml) containing sodium hydroxide (2.8 g) at ambient temperature with stirring, and the stirring was continued at 50° C. for half an hour. The precipitated crystals were collected by filtration, washed with ethanol and then recrystallized from methanol to give pale yellow crystals (3.0 g) of 2-amino-4-[2-(4-benzhydrylpiperazin-1-yl)ethylthiomethyl]thiazole, mp 159°-161° C.

Provenance & Evidence