Sodium → 5-Fluoro-2,3-dihydro-1-benzofuran-2-carboxylic acid

Participants

Reaction Steps

5-Fluorobenzofuran-2-carboxylic acid (2.4 g) was added to aqueous sodium hydroxide solution (3.3 g of sodium hydroxide in 50 ml of water). Sodium amalgam was added over 20 minutes (prepared from 1.1 g of sodium and 42 g of mercury). After a further 21/2 hours the solution was left to stand over the amalgam overnight. The mercury was separated and the solution filtered and then treated with excess 4 M sulphuric acid. The precipitated acid was filtered off and dried over P2O5 in vacuo (1.5 g) I.R. νmax 1720 cm-1.

Provenance & Evidence