HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Nitro-6-phenoxyphthalide → 5-Amino-6-phenoxyphthalide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Nitro-6-phenoxyphthalide | HCID 13069202 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Amino-6-phenoxyphthalide | HCID 13069206 | 67.5% |
Reaction Steps
950 mg of 5-nitro-6-phenoxyphthalide in 120 ml of methanol and 30 ml of tetrahydrofuran is hydrogenated in the presence of 2 g of Raney nickel within 3 hours at 20 bar, filtered, and concentrated. From methanol, 570 mg of 5-amino-6-phenoxyphthalide is obtained, mp 205°-206.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04411910 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-aa21e350c6104241979c4306d6cb88be |
| Source note | uspto-grants-1983_10 |