4-Fluoroaniline → HCID 51776821, compound

HRID 648258Notes

Reaction equation

[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Br[CH:10]([CH:14]([CH3:16])[CH3:15])[C:11]([OH:13])=[O:12].O(C1C=C(C=CC=1)CBr)C1C=CC=CC=1>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C@H:10]([C:11]([OH:13])=[O:12])[CH:14]([CH3:16])[CH3:15])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 97314-Fluoroaniline

HCID 112682-Bromoisovaleric acid

HCID 945441-(Bromomethyl)-3-phenoxybenzene

Product 1

HCID 51776821HCID 51776821, compound

Procedure

The acid, N-(4-fluorophenyl)valine is prepared as above from 4-fluoroaniline and α-bromoisovaleric acid and then reacted with m-phenoxybenzyl bromide, as above, to yield the m-phenoxybenzyl ester of N-(4-fluorophenyl)valine.

Sources & evidence

ORD record: ord-ed531f86580743b59f7e98005352eb30
Source dataset: uspto-grants-1983_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04411912

Reaction notes

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