反应详情

To the m-phenoxybenzyl ester of N-phenyl valine (1.2 mmole) is added 12.5% phosgene in benzene (2.3 mmole), cooled in an ice bath, and then dimethylaminopyridine (1.22 mmole). The reaction mixture is stirred at RT for 3 days. Then one ml of benzene, 0.15 g of dimethylaminopyridine and 2 ml of phosgene are added and the reaction stirred overnight at RT. The reaction is worked up using chloroform/water. The chloroform layer is washed with dilute sulfuric acid, water and brine, dried over sodium sulfate and filtered. The solvent is removed by rotoevaporation to yield the m-phenoxybenzyl ester of N-chloroformyl,N-phenyl valine.

1. temperaturecooled in an ice bath
2. stirringthe reaction stirred overnight at RT
3. washThe chloroform layer is washed with dilute sulfuric acid, water and brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. customThe solvent is removed by rotoevaporation