HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoisovaleric acid → N-(2-fluoro-4-chlorophenyl)valine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoisovaleric acid | HCID 11268 | — |
| Reactant | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Product | N-(2-fluoro-4-chlorophenyl)valine | HCID 54022058 | — |
Reaction Steps
N-(2-fluoro-4-chlorophenyl)valine and m-phenoxybenzyl bromide are reacted using the process of Example 42 to yield the m-phenoxybenzyl ester of N-(2-fluoro-4-chlorophenyl)valine, MS m/e 427.1 (M+, 4.1), 200 (100). N-(2-fluoro-4-chlorophenyl)valine is prepared by heating the potassium salt of α-bromoisovaleric acid and 2-fluoro-4-chloroaniline neat at 130° for about 2 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04411912 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-9d871a72a40245d5b892ae188db456d3 |
| Source note | uspto-grants-1983_10 |