Methyl iodide → N-methyl,N-(4-chlorophenyl)valine

HRID 648276Notes

Reaction equation

HRID 648276 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH:10]([CH3:12])[CH3:11])=[CH:4][CH:3]=1.[CH3:16]I>>[CH3:16][N:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[C@H:9]([C:13]([OH:15])=[O:14])[CH:10]([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 13796078N-(p-chlorophenyl)valine

Product 1

HCID 70536039N-methyl,N-(4-chlorophenyl)valine

Procedure

The α-cyano-m-phenoxybenzyl ester of N-(4-chlorophenyl)valine is reacted with methyl iodide using the procedure of Example 2 to yield the α-cyano-m-phenoxybenzyl ester of N-methyl,N-(4-chlorophenyl)valine, MS m/e 448.1 (M+).

Sources & evidence

ORD record
ord-7e6c148928314e21a7932bb034c251e1
Source dataset
uspto-grants-1983_10
Patent number
US04411912

Reaction notes

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