反应详情

A mixture of 2-fluoro-4-chlorotoluene (25.05 g), KMnO4 (55.04 g) and water (400 ml) is heated to reflux for about 5 hr. The reaction is then worked up by filtering while hot through Celite and the filtrate is acidified with 2 N HCl. White crystals are filtered off, dissolved in ether and washed with water and brine, dried over sodium sulfate, filtered and evaporated to yield 2-fluoro-4-chlorobenzoic acid.

1. temperatureis heated
2. temperatureto reflux for about 5 hr
3. filtrationby filtering while hot through Celite
4. filtrationWhite crystals are filtered off
5. dissolutiondissolved in ether
6. washwashed with water and brine
7. dry with materialdried over sodium sulfate
8. filtrationfiltered
9. customevaporated