HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → N-(2-fluoro-4-trifluoromethylphenyl)valin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 3-(2-Fluoro-4-trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione | HCID 20482737 | — |
| Product | N-(2-fluoro-4-trifluoromethylphenyl)valin | HCID 53766748 | — |
Reaction Steps
3-(2-Fluoro-4-trifluoromethylphenyl)-4-isopropyloxazolidine-2,5-dione is reacted with phenol using the procedure of Example 75 to give the phenyl ester of N-(2-fluoro-4-trifluoromethylphenyl)valine, which is reacted with NaHS using the method of Hirakayaski et al., Bull. Chem. Soc. Japan 38, 320 (1965) to give the sodium salt of the thioacid. ##STR27##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04411912 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-ba7cfefb609c4ee7ae1a19a453089c46 |
| Source note | uspto-grants-1983_10 |