HCID 19936753, compound → 2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-1H-imidazole

HRID 6483Notes

Reaction equation

HRID 6483 reaction equation
ClC1C=CC=CC=1CN1C(CCN[C@H](C(O)=O)CC2C=CC=CC=2)=CN=C1CCCC.[CH2:32]([C:36]1[N:37]([CH2:43][C:44]2[C:49]([F:50])=[CH:48][CH:47]=[CH:46][C:45]=2[Cl:51])[C:38](CO)=[CH:39][N:40]=1)[CH2:33][CH2:34][CH3:35]>>[CH2:32]([C:36]1[N:37]([CH2:43][C:44]2[C:49]([F:50])=[CH:48][CH:47]=[CH:46][C:45]=2[Cl:51])[CH:38]=[CH:39][N:40]=1)[CH2:33][CH2:34][CH3:35]

Participants

3

Reactant 2

HCID 19936753HCID 19936753, compoundHCID 54198642N-[2-{1 [(2-chlorophenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}ethyl]phenylalanine

Product 1

HCID 199367742-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-1H-imidazole

Procedure

The procedures of Example 1(ii iii) were used. From 7.63 g of crude 2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-1H-imidazole was obtained 2.8 q of 2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-5-hydroxymethyl-1H-imidazo le; mp 106°-108° C. (from ethyl acetate). This material was oxidized with manganese dioxide and worked up as described to give 0.88 g (63%) of 2-n butyl-2-(2-chloro-6-fluorophenyl)methyl-1H-imidazol-5-carboxaldehyde; mp 88°-90° C. (from ethyl acetate).

Sources & evidence

ORD record
ord-d2c9533997c74d79a948283e529ded3f
Source dataset
uspto-grants-1993_09
Patent number
US05248689

Reaction notes

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