HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-benzyloxycarbonyl-N-2-hydroxyethyl-2-pyrrolidinecarboxamide → (S)-N-(2-Hydroxyethyl)pyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-benzyloxycarbonyl-N-2-hydroxyethyl-2-pyrrolidinecarboxamide | HCID 13564346 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-N-(2-Hydroxyethyl)pyrrolidine-2-carboxamide | HCID 12136434 | 99.9% |
Reaction Steps
In 70 ml of methanol was dissolved 5.92 g of compound (79) and the compound was catalytically reduced by an ordinary method using 10% palladium-carbon as a catalyst. After the reaction, the catalyst and the solvent were removed to provide 3.2 g of syrupy (S)-N-2-hydroxyethyl-2-pyrrolidinecarboxamide (53). The product was solidified when it was refrigerated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04610821 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-78a0030d60754c27bf06653ff5cdac70 |
| Source note | uspto-grants-1986_09 |