HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(11-Mercaptoundecylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Ethyl 4-(11-bromoundecylamino)benzoate | HCID 20482498 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(11-Mercaptoundecylamino)benzoic acid | HCID 20482587 | — |
Reaction Steps
A solution of 10 g. of ethyl 4-[(11-bromoundecyl)amino]benzoate and 2.0 g. of thiourea in 80% of 95% ethanol is stirred under reflux for 3 hours, allowed to cool, treated with 12 ml. of 10 N aqueous sodium hydroxide solution and again stirred under reflux for 2 hours. The mixture is acidified with dilute hydrochloric acid and filtered. The solid is recrystallized from ethanol-water to yield the product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04411903 |
| Source dataset | uspto-grants-1983_10 |
| ORD ID | ord-28019d7ec28748d8a711b23df4696152 |
| Source note | uspto-grants-1983_10 |