HCID 20482499, compound → HCID 20482497, compound

Participants

Reaction Steps

A mixture of 7.6 g. ethyl 4-(6-methanesulfonyloxyhexadecylamino)benzoate and 5.5 g. of potassium thioacetate in 200 ml. of acetone is stirred under reflux for 3 hours and evaporated. The residue is positioned between methylene chloride and water and the organic layer is separated, dried and evaporated. Recrystallization of the residual solid form hexane affords the product as a light, tan solid. Hydrolysis of the product by the method of Example 10 affords 4-(6-mercaptohexadecylamino)benzoic acid.

Provenance & Evidence