Sodium methanesulfinate → HCID 178433494, compound

HRID 648368Notes

Reaction equation

HRID 648368 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([OH:8])[C:5](Cl)=[C:4]([OH:10])[N:3]=1.[CH3:11][S:12]([O-:14])=[O:13].[Na+]>CS(C)=O>[CH3:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([S:12]([CH3:11])(=[O:14])=[O:13])=[C:4]([OH:10])[N:3]=1

Participants

4

Reactant 2

HCID 2733271Sodium methanesulfinateHCID 178433463HCID 178433463, compound

Product 1

HCID 178433494HCID 178433494, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

16 g (0.1 mole) of 2-methyl-5-chloro-4,6-dihydroxypyrimidine and 11.2 g (0.11 mole) of sodium methylsulfinate are stirred in 50 ml of dimethyl sulfoxide for 4 hours at 125°-130° C. The suspension is filtered clear at 90° C. and chloroform is added to the filtrate. The flocculent precipitate is isolated by filtration and well dried, affording 9.4 g of approx. 90% product which is used for the further reaction without being purified.

Workup

  1. filtrationThe suspension is filtered clear at 90° C.
  2. additionchloroform is added to the filtrate
  3. customThe flocculent precipitate is isolated by filtration
  4. customwell dried

Sources & evidence

ORD record
ord-0636687cd50f4220958ae642fff424c9
Source dataset
uspto-grants-1983_10
Patent number
US04412074

Reaction notes

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