2-n-butyl 4-chloro 1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole → {1-(2-chlorophenyl)methyl-2-n butyl-1H-imidazol-5-yl}methyl-alpha-ethylphenylalanine methyl ester

Participants

Reaction Steps

The procedure of Example 4 (i), Method A, was followed using a-ethylphenylalanine methyl ester in place of α-methyl-phenylalanine methyl ester to give N-[{1-(2-chlorophenyl)methyl-2-n butyl-1H-imidazol-5-yl}methyl-α-ethylphenylalanine methyl ester. Hydrolysis of the ester using the procedure of Example 2 (ii), followed by treatment with hydrochloric acid, gave the title compound as the dihydrochloride salt; mp 209°-211° C.

Provenance & Evidence