Methanol → 2-(2-Amino-4-thiazolyl)-2-propoxyiminoacetic acid

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A solution of ethyl 2-n-propoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate (syn isomer) (10 g.) in a mixture of tetrahydrofuran (39 ml.), methanol (39 ml.) and 1 N sodium hydroxide (75.8 ml.) was stirred at 35° to 40° C. for 5 hours. After the resultant solution was concentrated under reduced pressure, the aqueous residue was adjusted to pH2.5 with 10% hydrochloric acid. The precipitates were collected by filtration and dried to give 2-n-propoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid (syn isomer) (6.2 g.), mp. 161° C. (dec.).

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