Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-ethoxyiminoacetic acid

HRID 648412Notes

Reaction equation

HRID 648412 reaction equation
[CH2:1]([O:3][N:4]=[C:5]([C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1)[C:6]([O-:8])=[O:7])[CH3:2].[C:15](OC(=O)C)(=[O:17])C>C(O)=O>[CH2:1]([O:3][N:4]=[C:5]([C:9]1[N:10]=[C:11]([NH:14][CH:15]=[O:17])[S:12][CH:13]=1)[C:6]([OH:8])=[O:7])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 53424234HCID 53424234, compound

Product 1

HCID 544580772-(2-Formamidothiazol-4-yl)-2-ethoxyiminoacetic acidYield 87.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2-Ethoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate acid (syn isomer) (100 g.), formic acid (85.5 g.) and acetic anhydride (190.1 g.) were treated according to a similar manner to that of Example 7(a) (5) to give 2-ethoxyimino-2-(2-formamido-1,3-thiazol-4-yl)acetic acid (syn isomer) (99.1 g.).

Sources & evidence

ORD record
ord-98b8ce3021044d2c89285f240df1d4ef
Source dataset
uspto-grants-1983_10
Patent number
US04411898

Reaction notes

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