Water → HCID 14127357, compound

Participants

Reaction Steps

To a solution of 5.7 g (0.022 mole) of trans-4 -phenyl-1-(phenylmethyl)-3-pyrrolidinecarbonitrile (Helv. Chim. Acta, 64, 2203 (1981)) in 30 ml tetrahydrofuran was added 0.83 g (0.022 mmol) of lithium aluminum hydride in portions under nitrogen. The reaction mixture was then stirred at room temperature for 18 hours. To the resulting suspension were added 1 ml of water, 0.8 ml of 40% sodium hydroxide, and 3 ml of water. The grainy precipitate was filtered and washed with tetrahydrofuran. The combined filtrates were concentrated to give 5.5 g of 4-phenyl-1-(phenylmethyl)-3-pyrrolidinemethanamine.

Provenance & Evidence