Methanol → HCID 20144947, compound

Participants

Reaction Steps

To 0.78 g (5 mmol) 2-pyridine-N-oxide carboxaldehyde (1) in 15 ml methanol was added 0.58 g (5 mmol) methyl 3-aminocrotonate and 0.58 g (5 mmol) methyl acetoacetate and the resulting solution was refluxed for 18 hours. The cooled reaction mixture was filtered to give a yellow solid that was triturated with hexane to give pure (2), m.p. 225°-228°.

Provenance & Evidence