2-Acetamidopyridine → 2-[(2-chloro-3-methyl-1-oxobutyl)-amino]-beta-oxo-N-(2-pyridinyl)-3-trifluoromethyl-benzene propanamide

Beteiligte Stoffe

Reaktionsschritte

Using the procedure of Step A of Example 13, 10.16 g of 2-acetylaminopyridine, 106 ml of a hexane solution of n-butyllithium (1,4M) and 11.4 g of 2-(1-chloro-2-methylpropyl)-8-trifluoromethyl-4H-3,1-benzoxazin-4-one of Step A of example 3 were reacted to obtain 11.8 g of 2-[(2-chloro-3-methyl-1-oxobutyl)-amino]-β-oxo-N-(2-pyridinyl)-3-trifluoromethyl-benzene propanamide melting at 136°-138° C.

Herkunft & Nachweise