Acetic Acid → HCID 178475910, compound

HRID 648476Notes

Reaction equation

[CH3:1][CH:2]([CH:4]1[C:8]2=[N:9][C:10]3[C:11]([C:18]([F:21])([F:20])[F:19])=[CH:12][CH:13]=[CH:14][C:15]=3[C:16]([OH:17])=[C:7]2[C:6](=[N:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)[O:5]1)[CH3:3].[C:29]([OH:32])(=[O:31])[CH3:30]>>[C:29]([O:32][CH:4]([C:8]1[C:7]([C:6]([NH:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)=[O:5])=[C:16]([OH:17])[C:15]2[C:10](=[C:11]([C:18]([F:21])([F:19])[F:20])[CH:12]=[CH:13][CH:14]=2)[N:9]=1)[CH:2]([CH3:3])[CH3:1])(=[O:31])[CH3:30]

Participants

Reactant 2

HCID 176Acetic Acid

HCID 178440487HCID 178440487, compound

Product 1

HCID 178475910HCID 178475910, compound

Procedure

Using the procedure of Example 13, 6 g of 1,3-dihydro-3-(1-methylethyl)-1-[(2-pyridinyl)-imino]-5-trifluoromethyl furo-[3,4-b]-quinolin-9-ol and 120 ml of acetic acid were reacted to obtain 3.5 g of 1-[4-hydroxy-3-[(2-pyridinyl)-aminocarbonyl]-8-trifluoromethyl-2-quinolinyl]-2-methylpropyl acetate melting at 230° C.

Workup

customwere reacted

Sources & evidence

ORD record: ord-076fc3d7ac384ea9b2a01a8244edc81f
Source dataset: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04735951

Reaction notes

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