HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Toluenesulfonyl chloride → p-Toluenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | {3-[2-(3,4-Dimethoxyphenyl)ethyl]-2-phenyl-1,3-oxazolidin-5-yl}methanol | HCID 12877852 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | p-Toluenesulfonate | HCID 85570 | — |
| Product | HCID 21937638 | HCID 21937638 | — |
Reaction Steps
In an operation carried out in a manner similar to that described in Example 1, p-toluenesulfonyl chloride is added portionwise to a cooled to 10° C. solution of 2-phenyl-3-(3,4-dimethoxyphenylethyl)-5-(hydroxymethyl)oxazolidine in pyridine while the temperature is maintained below 25° C. to obtain a tosylate of the 2-hydroxymethyloxazolidine as intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04735961 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-d344f49efd674721aa5c7830f8ec58ed |
| Source note | uspto-grants-1988_04 |